/Mortality and morbidity in transsexual patients with cross-gender hormone treatment

Mortality and morbidity in transsexual patients with cross-gender hormone treatment

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Coition steroid treatment is associated with aspect effects. The legions of deaths next morbidity cases taking part in transsexual patients treated with cross-gender hormones were evaluated retrospectively and compared together with the expected multitude in a akin reference group of the population.

The number of deaths in male-to-female transsexuals was five times the number likely, due to increased numbers of suicide and death of unknown cause. Pool treatment with estrogen and cyproterone acetate in male-to-female transsexuals was associated amid a fold lengthen of thromboembolic events, hyperprolactinemia fold Superseded, depressive mood changes fold , afterwards transient elevation of liver enzymes.

Now both groups stubborn liver enzyme abnormalities could be attributed to other causes than sex steroids hepatitis B also alcohol abuse. A large amount of the morbidity was minor as well as reversible with boost treatment or passing discontinuation of hormone treatment. Thus, the dilemma of prescribing cross gender hormones in view of the needs of these patients is not resolved. Interpretation of possible piece effects and sensible clinical judgment persist the cornerstone of the clinical result to prescribe cross-gender hormones.

Furthermore, aficionado of up of that relatively young denizens to disclose durable side effects next to elucidate the association of copulation steroids with coronary heart disease, at the same time as well as efforts to reduce the risk of thromboembolic events, are enforced.

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  • Mortality and morbidity in transsexual subjects treated with cross-sex hormones.
  • Metabolism. Sep;38(9) Mortality and morbidity in transsexual patients with cross-gender hormone treatment. Asscheman H(1), Gooren LJ, Eklund. Mortality...
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  • The optimum steroid hormone treatment regimes for transsexual subjects treated with cross‐sex...
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Humanity and morbidity participate in transsexual patients by way of cross-gender hormone management Psychological evaluation has shown that sex reassignment increases the well-being of transsexual subjects 1 , 2 , 3. Cross-sex hormone treatment has an important role in acquiring the secondary sex characteristics of the desired sex 4. Transsexuals often start taking sex hormones at young to middle age and in higher than recommended dosages. Fearing loss of secondary characteristics of the reassigned sex, transsexual subjects usually continue hormones lifelong. Previous reports from our clinic, in 5 and 6 , assessed clinical endpoints, such as morbidity and mortality, in transsexuals receiving cross-sex hormones. Several studies have looked at the effects of cross-sex hormone administration on laboratory variables related to cardiovascular risk in transsexuals, finding partially favorable and partially unfavorable effects 7 , 8 , 9 , The skewed sex ratio in cardiovascular disease favoring women at all ages and the increasing incidence of cardiovascular disease after menopause were previously interpreted to indicate that estrogens are cardioprotective.
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